Spondyloarthritis & psoriatic arthritis
Diffuse idiopathic skeletal hyperostosis is associated with reduced lung function independent of structural lung abnormalities
Authors' conclusion
In long-term smokers, DISH was associated with lower lung function and volumes, not explained by structural lung abnormalities on CT. These findings suggest that DISH may be an extrinsic factor contributing to reduced lung function as a result of thoracic cage stiffening.
Study context
- Population
- Individuals with long-term smoking history from the NELSON lung cancer screening trial (100% male, mean age 60.4 years)subjects, diffuse idiopathic skeletal hyperostosis (DISH) present in 241 (6.7%)
- Participants
- 3,514 individuals
- Comparison
- DISH subjects compared to subjects without DISH
- DISHn = 241
- Outcome
- Respiratory Bronchiolitis Interstitial Lung Disease prevalence
Methodological detailsmultivariate linear regression with adjustment for participant factors and structural lung disease
- Multivariate linear regression with adjustment for participant factors and structural lung disease
Main finding
As reported in the abstract
P = 0.04
Further findings
Centrilobular emphysema prevalence · lower prevalence with DISH
P = 0.009
Airway wall thickness · greater with DISH
P < 0.001
| Outcome | Difference (ml) (95% CI) | |
|---|---|---|
| FEV1 (ml) | −150 (−160 to −140) | |
| −200−1000100Difference, ml (linear scale) |
| Outcome | Estimate |
|---|---|
| FEV1 (%)Lower with DISH | difference (multivariate linear regression) 4.4% (95% CI −7.1% to −1.7%) |
| Predicted FVCLower with DISH | difference (multivariate linear regression) 4.0% (95% CI −6.2% to −1.7%) |
| FVC (ml)Lower with DISH | difference (multivariate linear regression) 170 ml (95% CI −280 to −70) |
| CT measured lung volume | difference (multivariate linear regression) 210 ml (95% CI −40 to −1) |
- CT measured lung volume: lower with DISH; printed estimate lies outside its printed interval
Original publication
Diffuse idiopathic skeletal hyperostosis is associated with reduced lung function independent of structural lung abnormalities. Semin Arthritis Rheum. Published 31 October 2026. doi:10.
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