Spondyloarthritis & psoriatic arthritis
Sex differences in cytokines and adipokines in obese patients with psoriatic arthritis (PsA) and controls undergoing a weight loss intervention
Authors' conclusion
Women and men with PsA differed with regard to serum levels of cytokines and adipokines before and after weight loss.
Study context
- Population
- Patients with PsA aged 25–75 years with body mass index (BMI)≥33 kg/m², in a very low energy diet (VLED) weight loss intervention for 12 or 16 weeks (baseline (BL) BMI<40 or ≥40 kg/m²), and obese controls41 PsA, 39 controls
- Comparison
- Women vs men with PsA, at baseline and 6 months after a VLED weight loss intervention
- Controlsn = 39
- Primary endpoint
- Serum cytokine and adipokine levels by sex
- Follow-up
- BL and M6
Methodological detailsmatched controls (sex, age and weight)
- Matched controls (sex, age and weight)
Primary result
As reported in the abstract
BL
- IL-23, leptin and high molecular weight-adiponectin higher in women with PsA than men
- Interferon (IFN)-γ, IL-12/IL-23 p40 and IL-13 significantly lower in women
- Serum IL-23 significantly reduced at M6 vs BL in women but not in men with PsA
- Post hoc analysis
Further findings
Correlations of ∆IL-23 at M6 in women with PsA
- ∆IL-23 vs ∆DAS28-CRP (rS)
- 0.486, p=0.016
- ∆IL-23 vs ∆C reactive protein (CRP) (rS)
- 0.468, p=0.021
- ∆IL-23 vs ∆leptin (rS)
- 0.683, p<0.001
- ∆IL-23 vs ∆total-adiponectin (rS)
- −0.433, p=0.035
- Spearman's correlation
- None significant in men with PsA
Correlations of ∆DAPSA in women with PsA · M6
- ∆DAPSA vs ∆TNF-α (rS)
- 0.417, p=0.034
- ∆DAPSA vs ∆IL-1β (rS)
- 0.550, p=0.034
- ∆DAPSA vs ∆IFN-γ (rS)
- 0.414, p=0.035
- ∆DAPSA vs ∆leptin (rS)
- 0.410, p=0.038
- Spearman's correlation
- None significant in men with PsA
Original publication
Sex differences in cytokines and adipokines in obese patients with PsA and controls undergoing a weight loss intervention. RMD Open. Published 22 March 2024. doi:10.
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