Spondyloarthritis & psoriatic arthritis
Serum IL-23 significantly decreased in obese patients with psoriatic arthritis six months after a structured weight loss intervention
Authors' conclusion
Weight loss was associated with decreased levels of leptin and cytokines, in particular IL-23.
Study context
- Population
- Obese patients with PsA (body mass index (BMI) ≥ 33 kg/m²) and controls matched on sex, age and weightPsA and matched controls
- Exposure
- Serum cytokines and adipokines at M6 vs baseline (BL) after Very Low Energy Diet (VLED) weight loss intervention, in PsA and matched controls
- Outcome
- Change in serum cytokines and adipokines (Magnetic Luminex Assays)
- Follow-up
- M6
Methodological detailsbefore–after (baseline vs 6 months), matched controls (sex, age and weight), retrospectively registered
- Before–after (baseline vs 6 months)
- Matched controls (sex, age and weight)
- Retrospectively registered
Main finding
As reported in the abstract
Serum IL-23 in PsA
- M6 vs BL: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Serum leptin in PsA · M6Significantly decreased | P < 0.001 |
Serum tot-adiponectin and high molecular weight (HMW) adiponectin in PsA · M6
- Increased significantly
Cytokines and adipokines in controls · M6
- Similar findings were found in controls
Correlation of ∆BMI with ∆IL-23 in PsA
- rS
- 0.671
- p < 0.001
- Positive correlation
Correlations of ΔBMI with other changes in PsA
- Significant positive correlations with ΔDAS28CRP, ΔCRP, ΔTNF-α, ΔIL-13, ∆IL-17 and Δleptin
- Negative correlation with Δtot-adiponectin
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serum IL-23 significantly decreased in obese patients with psoriatic arthritis six months after a structured weight loss intervention. Arthritis Res Ther. Published 27 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →