Lupus & antiphospholipid syndrome
Unravelling the TCRβ repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE
Authors' conclusion
The TCRβ repertoire is significantly altered in SLE, with potential implications for diagnostics and therapeutics.
Study context
- Population
- Treatment-naive patients with SLE and healthy donors; blood samples
- Participants
- 50 vs 50
- Comparison
- Treatment-naive patients with SLE vs healthy donors
- SLEn = 50
- Healthy donorsn = 50reference
- Outcome
- Variances in the TCRβ repertoire between patients with SLE and healthy individuals, correlated with severity and subtypes of SLE
Methodological detailshigh-throughput sequencing, bioinformatics analysis
- High-throughput sequencing
- Bioinformatics analysis
Main finding
As reported in the abstract
TCRβ repertoire
- Nine hub TRBV genes identified as potential biomarkers for SLE with high diagnostic accuracy
- 9
Observational data: associations, not effects.
Original publication
Unravelling the TCRβ repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE. Lupus Sci Med. Published 19 January 2025. doi:10.
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