Lupus & antiphospholipid syndrome
Nomogram for predicting proliferative lupus nephritis in patients with low-level proteinuria
Authors' conclusion
Some 41.7% of the patients with low-level proteinuria exhibited proliferative LN when biopsied.
Study context
- Population
- Biopsy-proven LN patientsbiopsy-proven LN
- Participants
- 671 patients
- Comparison
- Low-level proteinuria vs high-level proteinuria
- Low-level proteinurian = 103
- Outcome
- Proliferative LN in patients with low-level proteinuria (predictive nomogram)
Methodological detailsprediction model development, least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression, internal validation by bootstrap-resampling
- Prediction model development
- LASSO regression and multivariate logistic regression
- Internal validation by bootstrap-resampling
Performance
As reported in the abstract
Proliferative LN in low-level proteinuria; nomogram performance
| Test or model | Value | AUC | Bootstrapped AUC |
|---|---|---|---|
| Low-level proteinuria | 41.7% | 0.900 (95% CI 0.840-0.960) | 0.894 (95% CI 0.832-0.965) |
Low-level proteinuria
Value41.7%
AUC0.900 (95% CI 0.840-0.960)
Bootstrapped AUC0.894 (95% CI 0.832-0.965)
Further findings
- Activity Index and Chronicity Index (low-level proteinuria)
- 5 · IQR 4–7
Long-term adverse renal events-free survival
- Preferable in the low-level proteinuria group
Original publication
Nomogram for predicting proliferative lupus nephritis in patients with low-level proteinuria. Rheumatology (Oxford). Published 16 January 2025. doi:10.
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