Lupus & antiphospholipid syndrome
Development and validation of a nomogram for predicting the interstitial fibrosis and tubular atrophy in patients with lupus nephritis
Authors' conclusion
With excellent predictive abilities, the nomogram may provide a simple and reliable tool to distinguish LN patients with IFTA
Study context
- Population
- Patients with biopsy-proven LN at the Affiliated Hospital of Qingdao University and Fujian Medical University Union Hospitaldevelopment and validation cohorts
- Participants
- 303 patients
- Comparison
- Interstitial fibrosis and tubular atrophy (IFTA) vs non-IFTA
- Outcome
- Prediction of IFTA in LN (discrimination by C-index)
Methodological detailstwo-centre, least absolute shrinkage and selection operator (LASSO) regression, multivariable logistic regression, bootstrapping internal validation, nomogram
- Two-centre
- LASSO regression
- Multivariable logistic regression
- Bootstrapping internal validation
- Nomogram
Performance
As reported in the abstract
Model discrimination (C-index)
- C-index, development model
- 0.794 (95% CI 0.734-0.854)
- C-index, internal validation
- 0.857 (95% CI 0.776-0.938)
- Calibration
- good calibration
Original publication
Development and validation of a nomogram for predicting the interstitial fibrosis and tubular atrophy in patients with lupus nephritis. Rheumatology (Oxford). Published 17 September 2024. doi:10.
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