Sjögren's disease & overlap diseases
Unravelling interstitial pneumonia with autoimmune features (IPAF), VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum
Authors' conclusion
At MCTD diagnosis, fulfilment of IPAF and/or VEDOSS criteria was not predictive of evolution toward SSc, whereas antiphospholipid antibodies and low C3 and/or C4 were predictive of an evolution toward SLE.
Study context
- Population
- Mixed connective tissue disease (MCTD) patients in the French MCTD cohort
- Exposure
- IPAF or VEDOSS criteria fulfilment vs non-fulfilment at MCTD diagnosis
- IPAFn = 38
- VEDOSSn = 293
- Outcome
- Predictive value of IPAF, VEDOSS and dCTD classification criteria variables for progression to a dCTD
Methodological detailsFrench MCTD cohort
- French MCTD cohort
Main finding
As reported in the abstract
Progressed into a differentiated connective tissue diseases (dCTD) (all MCTD)
111
34.3%
Progressed into systemic sclerosis (SSc)
50
15.4%
Progressed into systemic lupus erythematosus (SLE)
40
12.3%
Progressed into Sjögren's disease
11
3.4%
Observational data: associations, not effects.
Further findings
| Outcome | IPAF | No IPAF | VEDOSS | No VEDOSS | P value |
|---|---|---|---|---|---|
| Progression to a dCTD by IPAF criteria at diagnosisIPAF vs No IPAF | 39.5% | 26.2% | — not stated in the abstract | — not stated in the abstract | P = 0.09 |
| Progression to SSc by VEDOSS criteria at diagnosisVEDOSS vs No VEDOSS | — not stated in the abstract | — not stated in the abstract | 15.7% | 12.9% | P = 0.8 |
— not stated in the abstract
Baseline predictors of evolution
- aPL predictive of evolution toward SLE
- P = 0.01
- Low C3 and/or C4 predictive of evolution toward SLE
- P = 0.04
- SSc classification criteria did not predict evolution toward SSc
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →