Thrombotic manifestations in pediatric Behcet syndrome: A multicenter comparative study from the EUROFEVER registry
Authors' conclusion
Thrombosis was reported at BS presentation in one fifth of cases. Pustolosis and fever were more frequently concomitant to thrombosis. Sinus veins were the most frequent site.
Study context
- Population
- Pediatric Behçet syndrome patients in the EUROFEVER registry
- Participants
- 37 vs 74
- Comparison
- Pediatric Behçet syndrome (BS) with thrombosis vs without thrombosis
- T+n = 37
- T-n = 74reference
- Outcome
- Characteristics at onset, T+ vs T-
- Follow-up
- BS onset
Methodological detailsmulticentre, registry-based (EUROFEVER), matched 2:1 (same rheumatology units)
- Multicentre
- Registry-based (EUROFEVER)
- Matched 2:1 (same rheumatology units)
Main finding
As reported in the abstract
- T+ vs T-: P = 0.015
- T+ vs T-: P = 0.002
- T+ vs T-: P < 0.001
- T+ vs T-: P < 0.001
- T+ vs T-: P = 0.022
- T+ vs T-: P = 0.034
- Matched 2:1
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics at onset, T+ vs T- · BS onsetT- vs T+ · ICBD criteria fulfillment higher in T- | P = 0.015 |
| Characteristics at onset, T+ vs T- · BS onsetT+ vs T- | P = 0.002 |
| Characteristics at onset, T+ vs T- · BS onsetT- vs T+ · Pustulosis more frequent in T- | P < 0.001 |
| Characteristics at onset, T+ vs T- · BS onsetT- vs T+ · Gastrointestinal symptoms more frequent in T- | P < 0.001 |
| Characteristics at onset, T+ vs T- · BS onsetT- vs T+ · Ocular involvement more frequent in T- | P = 0.022 |
| Characteristics at onset, T+ vs T- · BS onsetT+ vs T- · Neurological symptoms more often in T+ | P = 0.034 |
- Characteristics at onset, T+ vs T-: Caucasian patients more often T-, Turkish patients more frequent in T+
Thrombosis site (T+)
- Cerebral sinuses involved
- 21/37, 56.8 %
Features in T+ patients who developed thrombosis later (subgroup)
- Oral aphthosis more frequent at BS onset
- P = 0.003
- Genital aphthosis more frequent at BS onset
- P = 0.014
- Pustulosis coexisted with thrombosis
- P = 0.005
- Fever coexisted with thrombosis
- P = 0.043
Immunomodulatory treatment (T+)
- After thrombosis
- 35/37 (94.6 %)
- Pre-thrombosis
- 16/29 (55.2 %)
Thrombosis recurrence
- Recurrence
- 6/31(19.4 %)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Thrombotic manifestations in pediatric Behcet syndrome: A multicenter comparative study from the EUROFEVER registry. Semin Arthritis Rheum. Published 23 April 2024. doi:10.
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