Bone health and physical activity in adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study
Authors' conclusion
Adolescents with JIA had lower total body aBMD and BMC compared with sex- and age-matched controls without JIA. Group differences in bone outcomes were not associated with the lower MVPA participation of adolescents with JIA.
Study context
- Population
- Adolescents aged 10–20 years with and without juvenile idiopathic arthritis (JIA)
- Participants
- 21 vs 21
- Comparison
- Adolescents with JIA vs sex- and age-matched controls without JIA
- JIAn = 21
- Controlsn = 21reference
- Outcome
- Total body BMC and aBMD (height-adjusted z-scores, dual X-ray absorptiometry)
Methodological detailssex- and age-matched controls, multiple linear mixed effects models
- Sex- and age-matched controls
- Multiple linear mixed effects models
Main finding
As reported in the abstract
Total body aBMD and BMC z-scores, adjusted for sex, maturity, MVPA, TSLH and lean mass
Β (areal bone mineral density (aBMD) z-score)
−0.58
95% CI −1.10 to −0.07P = 0.03
JIA
Β (bone mineral content (BMC) z-score)
−0.47
95% CI −0.91 to −0.03P = 0.04
JIA
Observational data: associations, not effects.
Further findings
| Outcome | Difference (min/day) |
|---|---|
| Mean daily MVPALower in JIA | 22.0 |
Association of moderate-to-vigorous physical activity (MVPA) with bone outcomes
- MVPA vs aBMD, β
- −0.01 (−0.01 to 0.01), p = 0.32 (95% CI)
- MVPA vs BMC, β
- 0.00 (−0.01 to 0.00), p = 0.39 (95% CI)
- MVPA was not associated with aBMD or BMC
Association of lean mass with bone outcomes
- Lean mass vs aBMD, β
- 0.05 (0.01 to 0.09) g/cm², p = 0.03 (95% CI)
- Lean mass vs BMC, β
- 0.06 (0.03 to 0.10) g, p < 0.001 (95% CI)
- Positively associated
Original publication
Bone health and physical activity in adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study. Pediatr Rheumatol Online J. Published 19 April 2024. doi:10.
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