Validation of the PEDiatric Behçet’s Disease classification criteria: an evidence-based approach
An erratum to this article was published (Rheumatology (Oxford), 1 Dec 2024 ↗)
Authors' conclusion
The PEDBD criteria were very specific, while the ICBD were more sensitive.
Study context
- Population
- Pediatric patients with Behçet's disease (BD) and confounding autoinflammatory diseases randomly selected from the Eurofever Registry70 BD
- Participants
- 210 patients
- Comparison
- PEDBD vs ISG vs ICBD classification criteria
- Outcome
- Sensitivity, specificity and accuracy of the criteria vs table consensus
Methodological detailsevidence-based validation, clinicians blinded to original diagnosis, table consensus as gold standard (agreement ≥ 80%), 11 experienced clinicians/researchers blinded to the original diagnosis evaluated the patients
- Evidence-based validation
- Clinicians blinded to original diagnosis
- Table consensus as gold standard (agreement ≥ 80%)
- 11 experienced clinicians/researchers blinded to the original diagnosis evaluated the patients
Performance
As reported in the abstract
Performance in confirmed BD vs confounding diseases
| Test or model | Sensitivity | Specificity | Accuracy |
|---|---|---|---|
| ISG | 0.50 | 1.00 | 0.91 |
| ICBD | 0.79 | 0.97 | 0.94 |
| PEDBD | 0.58 | 0.99 | 0.92 |
Sensitivity
ISG0.50
ICBD0.79
PEDBD0.58
Specificity
ISG1.00
ICBD0.97
PEDBD0.99
Accuracy
ISG0.91
ICBD0.94
PEDBD0.92
Further findings
Expert consensus reached · end of third round
- Consensus reached
- 139/210 patients (66.2%)
- Confirmed BD (consensus ≥80%)
- 24
- Probable BD (agreement 60-79%)
- 10
BD distinctive elements vs confounding diseases
- Older age at onset, oral and genital ulcers, skin papulo-pustular lesions, positive pathergy test and posterior uveitis were BD distinctive elements
Original publication
Validation of the PEDiatric Behçet’s Disease classification criteria: an evidence-based approach. Rheumatology (Oxford). Published 22 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →