Elevation of IL ‐17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders
Authors' conclusion
Elevation of IL-17 family cytokines is a hallmark of KD and may help distinguish KD from its clinical mimics.
Study context
- Population
- Children with kawasaki disease (KD), other pediatric inflammatory diseases, febrile and healthy controls
- Participants
- 30 / 26 / 23 / 25 / 13 / 14 / 10 / 9 / 37 / 28
- Comparison
- KD vs febrile controls and other pediatric inflammatory diseases
- Healthy controlsn = 30reference
- Febrile controlsn = 26reference
- KDn = 23
- Multisystem inflammatory syndrome in children (MIS-C)n = 25
- Macrophage activation syndromen = 13
- Systemic juvenile idiopathic arthritisn = 14
- Nonsystemic juvenile idiopathic arthritisn = 10
- Juvenile dermatomyositisn = 9
- KD (validation)n = 37
- Febrile controls (validation)n = 28reference
- Outcome
- Diagnostic markers distinguishing KD from other pediatric inflammatory diseases
Methodological detailsproximity extension assay proteomic profiling, derivation and validation sets
- Proximity extension assay proteomic profiling
- Derivation and validation sets
Performance
As reported in the abstract
IL-17A discriminating KD from febrile controls (AUC)
| Test or model | AUC (derivation set) | AUC (validation set) |
|---|---|---|
| KD | 0.95 (95% CI 0.89-1.00) | 0.91 (0.85-0.98) |
KD
AUC (derivation set)0.95 (95% CI 0.89-1.00)
AUC (validation set)0.91 (0.85-0.98)
Further findings
Elevation of all three IL-17-family cytokines
- KD with coronary artery aneurysms
- 19 of 20
- Observed in over 50% of KD patients
- Rare in all other comparator groups
Original publication
Elevation of IL ‐17 Cytokines Distinguishes Kawasaki Disease From Other Pediatric Inflammatory Disorders. Arthritis Rheumatol. Published 20 November 2023. doi:10.
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