Lupus & antiphospholipid syndrome
The role of peritubular capillaritis in severity of lupus nephritis
Authors' conclusion
The findings of this study suggest that ptc is a frequently observed pathological feature in patients with lupus nephritis. Furthermore, the severity of ptc appears to be positively associated with elevated serum creatinine levels, and higher ptc scores are more commonly detected in cases with a high activity index.
Study context
- Population
- Patients with LN whose renal biopsy specimens were re-evaluated45 (78.9%) female
- Participants
- 57 patients
- Outcome
- Frequency of peritubular capillaritis (ptc) and its relationship with active and chronic lesions in LN
Methodological detailsbiopsy re-evaluation, Banff classification ptc scoring
- Biopsy re-evaluation
- Banff classification ptc scoring
Main finding
As reported in the abstract
Ptc identified
45
78.9%
Ptc score 1
20
35.08%
Ptc score 2
20
35.08%
Ptc score 3
5
8.7%
Observational data: associations, not effects.
Further findings
Creatinine >1.20 mg/dL vs Normal creatinine
Severe ptc (scores 2 or 3) by serum creatinine
P < 0.001
Class 4 vs Class 3
Severe ptc by LN class
P = 0.005
Activity index ≥6 vs Activity index <6
High ptc scores by activity index
P = 0.032
Chronicity index and ptc
- No significant correlation
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →