The role of nailfold video-capillaroscopy in the assessment of dermatomyositis
Authors' conclusion
DM patients can experience varying degrees of aberrant NVC patterns, which can impact ILD risk and warrant clinical vigilance.
Study context
- Population
- Dermatomyositis (DM) patients who underwent Nailfold Video-capillaroscopy (NVC), Affiliated Hospital of Nantong University, September 2017 to September 2022
- Participants
- 76 / 26 / 33
- Exposure
- DM vs ASS and systemic sclerosis (SSc) controls; NVC-based clusters within DM
- DMn = 76
- ASSn = 26reference
- SScn = 33reference
- Outcome
- NVC alterations and their implications for disease progression in DM
Methodological detailssingle-centre, unsupervised machine learning (hierarchical clustering analysis)
- Single-centre
- Unsupervised machine learning (hierarchical clustering analysis)
Main finding
As reported in the abstract
Anomalous NVC patterns in DM
DM
73.7%
Observational data: associations, not effects.
Further findings
Clinical features with abnormal vs normal NVC in DM
- Abnormal NVC: significantly higher prevalence of RP and greater likelihood of triple combination therapy
NVC changes, DM vs controls
- Milder NVC changes in DM than SSc
- NVC abnormalities more prominent in DM than ASS
Interstitial lung disease (ILD) and survival by NVC cluster (two clusters) · follow-up to December 2022
- Cluster 1 more likely to develop ILD
- Survival did not differ significantly between clusters
Original publication
The role of nailfold video-capillaroscopy in the assessment of dermatomyositis. Rheumatology (Oxford). Published 17 December 2024. doi:10.
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