Clinical Characteristics of Anti‐Synthetase Syndrome: Analysis From the Classification Criteria for Anti‐Synthetase Syndrome Project
Authors' conclusion
We identified key clinical and serological variables associated with ASSD, which will help clinicians and offer insights into the development of data-driven classification criteria for ASSD.
Study context
- Population
- Patients with anti-synthetase syndrome (ASSD) and controls with systemic autoimmune rheumatic disease (SARDs) and/or interstitial lung disease (ILD) in the international, multicenter CLASS project database
- Participants
- 948 vs 1,077
- Comparison
- ASSD vs controls with mimicking conditions
- ASSDn = 948
- Controlsn = 1,077reference
- Outcome
- Clinical and serological features associated with an ASSD diagnosis
Methodological detailsinternational, multicenter, univariable logistic regression, multivariable Ridge regression, randomly selected subset of the cohort
- International
- Multicenter
- Univariable logistic regression
- Multivariable Ridge regression
- Randomly selected subset of the cohort
Main finding
As reported in the abstract
Features associated with ASSD diagnosis
- Joint, muscle, lung, skin and cardiac involvement more prevalent in ASSD than controls
- Clinical variables associated with ASSD: arthritis, diffuse myalgia, muscle weakness, muscle enzyme elevation, ILD, mechanic's hands, secondary pulmonary hypertension due to ILD, RP, unexplained fever
- Serological variables associated with ASSD: Jo-1 and non-Jo-1 anti-synthetase autoantibodies, ANA with cytoplasmic pattern, anti-Ro52 autoantibodies
- Not differentiating or inversely associated with ASSD: isolated arthralgia, dysphagia, EMG/MRI/muscle biopsy findings suggestive of myopathy, inflammatory rashes, myocarditis, PAH
Observational data: associations, not effects.
Original publication
Clinical Characteristics of Anti‐Synthetase Syndrome: Analysis From the Classification Criteria for Anti‐Synthetase Syndrome Project. Arthritis Rheumatol. Published 17 December 2024. doi:10.
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