Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies–related interstitial lung disease
Authors' conclusion
NVC findings, sKL-6 levels, and autoantibodies are valuable in identifying and monitoring ILD in IIM, highlighting their role in early diagnosis and management.
Study context
- Population
- Idiopathic inflammatory myopathies (IIM) patients from a reference centre (34% male, median age 55.3 ± 24 years, disease duration 6.8 ± 7 years)
- Participants
- 95 patients
- Exposure
- IIM with interstitial lung disease (ILD) vs IIM without ILD
- Outcome
- Relationship between NVC abnormalities, sKL-6 levels and pulmonary outcomes
Methodological detailssingle reference centre, Spearman's rank correlation, multiple logistic regression
- Single reference centre
- Spearman's rank correlation
- Multiple logistic regression
Main finding
As reported in the abstract
NVC abnormalities, sKL-6 and lung outcomes
- ILD associated with avascular zones
- P = 0.004
- ILD associated with capillary loss
- P = 0.04
- ILD associated with microhaemorrhages
- P = 0.04
- Capillary loss vs %FVC, rs
- rs = −0.46, P = 0.001
- Enlarged capillaries vs %FVC, rs
- rs = −0.57, P < 0.0001
- Capillary loss vs %DLCO, rs
- rs = −0.32, P = 0.04
- Enlarged capillaries vs %DLCO, rs
- rs = −0.23, P = 0.03
- sKL-6 vs ILD, rs
- rs = 0.77, P = 0.0004
- sKL-6 vs microhaemorrhages, rs
- rs = 0.21, P = 0.04
- sKL-6 vs avascular areas, rs
- rs = 0.64, P = 0.03
- sKL-6 vs %FVC, rs
- rs = −0.47, P = 0.001
- sKL-6 vs %DLCO, rs
- rs = −0.59, P = 0.005
Observational data: associations, not effects.
Further findings
Predictors of ILD (multiple logistic regression)
- Predictors of ILD: male sex, respiratory symptoms, %FVC, %DLCO, sKL-6, anti-Jo1 positivity and nailfold videocapillaroscopy (NVC) abnormalities
Original publication
Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies–related interstitial lung disease. Rheumatology (Oxford). Published 10 December 2024. doi:10.
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