Nailfold videocapillaroscopy findings are associated with Idiopathic inflammatory myopathy (IIM) subtypes and IFN activation
Authors' conclusion
IIM patients exhibit distinct NVC abnormalities, which vary across different MSA subtypes.
Study context
- Population
- Patients with IIM, single centre
- Participants
- 55 patients
- Exposure
- Nailfold videocapillaroscopy (NVC) features across myositis-specific antibody (MSA) subgroups: MDA5 vs ARS vs MSA
- Outcome
- NVC features in IIM subtypes and correlations with MSA subtypes, disease activity, cytokine profiles and ISG expression
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
NVC scores, MDA5(+) vs ARS(+)
- NVC abnormalities observed in most IIM patients, with significant differences among MSA subgroups
- MDA5 (+) vs ARS (+): P < 0.01
- MDA5 (+) vs ARS (+): P < 0.05
- MDA5 (+) vs ARS (+): P < 0.01
- MDA5 (+) vs ARS (+): P < 0.05
Observational data: associations, not effects.
Further findings
Interferon-stimulated gene (ISG) expression and cytokines by disease activity
- ISG expression and cytokine levels upregulated in IIM; active disease showed significantly higher levels of certain ISGs and cytokines vs clinically stable patients
Correlation of NVC scores with ISGs and cytokines
- Microhemorrhage, capillary dilation and capillary density positively correlated with MX1, IFI27, IP-10, RANTES and GROα
- P < 0.05
- Giant capillary related to IFI27, SDF-1α, IP-10, RANTES and GROα
- P < 0.05
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Nailfold videocapillaroscopy findings are associated with IIM subtypes and IFN activation. Arthritis Res Ther. Published 20 March 2025. doi:10.
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