Longitudinal changes in nailfold videocapillaroscopy findings differ by myositis-specific autoantibody in idiopathic inflammatory myopathy
Authors' conclusion
The results of this study demonstrate that longitudinal changes in NVC findings may vary depending on myositis-specific Ab expression.
Study context
- Population
- IIM patients expressing myositis-specific autoantibodies (anti-ARS, anti-TIF1, anti-MDA5), single site
- Participants
- 71 patients
- Exposure
- Longitudinal nailfold videocapillaroscopy (NVC) changes in IIM by myositis-specific autoantibody: anti-MDA5 vs anti-TIF1 vs anti-ARS
- Anti-MDA5n = 25
- Anti-TIF1n = 24
- Anti-ARSn = 22
- Outcome
- Change in NVC findings (giant, enlarged and reduced capillaries, haemorrhages, ramification, disorganization, capillary loss) from baseline to after disease activity stabilization
- Follow-up
- After disease activity stabilization
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Longitudinal change in NVC findings, baseline to after stabilization
- Enlarged capillaries improved after stabilization in anti-MDA5
- P < 0.0001
- Reduced capillaries improved after stabilization in anti-MDA5
- P < 0.05
- Significant reduction in haemorrhages in all three groups
- P < 0.0001 for each group
Observational data: associations, not effects.
Further findings
Reduced capillaries at baseline — Anti-TIF1 vs Anti-MDA5
P < 0.0001
| Outcome | Anti-MDA5 | Anti-TIF1 | Anti-ARS | P value |
|---|---|---|---|---|
| Enlarged capillaries at baselineAnti-TIF1 vs Anti-ARS | — not stated in the abstract | 88% | 55% | P < 0.05 |
| Reduced capillaries at baselineAnti-TIF1 vs Anti-ARS | P < 0.0005 |
— not stated in the abstract
Enlarged capillaries at baseline
- Frequency different among the three groups
Original publication
Longitudinal changes in nailfold videocapillaroscopy findings differ by myositis-specific autoantibody in idiopathic inflammatory myopathy. Rheumatology (Oxford). Published 22 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →