Integrating carotid Doppler, greyscale US, and aortic oscillometry to evaluate macroangiopathy in myositides: the MYOCARD cohort
Authors' conclusion
In one of the largest CV surrogate marker studies in IIM, patients exhibited increased carotid pulsatility, resistance, and atherosclerosis compared with controls.
Study context
- Population
- Patients with idiopathic inflammatory myopathies (IIM) and healthy controls (MYOCARD cohort)
- Participants
- 82 vs 88
- Exposure
- IIM patients vs healthy controls
- IIMn = 82
- Healthy controlsn = 88reference
- Outcome
- Colour Doppler US (CDUS), greyscale US (GSUS) and oscillometric indices of macroangiopathy (carotid intima-media thickness (cIMT), carotid RI and PI, cfPWV)
Methodological detailscase-control comparison with healthy controls
- Case-control comparison with healthy controls
Main finding
As reported in the abstract
Carotid macroangiopathy markers, IIM vs controls
- IIM vs Healthy controls: Padj = 0.032
- IIM vs Healthy controls: Padj = 0.015
- IIM vs Healthy controls: Padj = 0.013
- IIM vs Healthy controls: Padj = 0.012
- IIM vs Healthy controls: Padj = 0.039
Observational data: associations, not effects.
Further findings
Resistance (RI) and pulsatility (PI) of CCA and internal carotid arteries (ICA) vs lung function (vital capacity)
- RI and PI of CCA and ICA higher in patients with lower lung function vital capacity (all Ps < 0.05)
Carotid-femoral pulse wave velocity (cfPWV) correlations
- Age, ρ (P < 0.001)
- 0.546
- Mean arterial pressure, ρ (P = 0.003)
- 0.331
- Diabetes, P
- 0.007
- Hyperlipidaemia, P
- 0.032
- Lung CO diffusion, ρ (P = 0.031)
- −0.329
Original publication
Integrating carotid Doppler, greyscale US, and aortic oscillometry to evaluate macroangiopathy in myositides: the MYOCARD cohort. Rheumatology (Oxford). Published 13 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →