Spondyloarthritis & psoriatic arthritis
The faecal microbiota is distinct in HLA-B27+ ankylosing spondylitis patients versus HLA-B27+ healthy controls
Authors' conclusion
Consistent with some previous studies, our study demonstrates in patients with AS associations with Coprococcus, Bacteroides, and Ruminococcus.
Study context
- Population
- Patients with HLA-B27+ AS and healthy adults who underwent 16S sequencing and genotyping as part of the TwinsUK Programme
- Participants
- 29 vs 43
- Exposure
- HLA-B27+ AS patients vs HLA-B27+ healthy controls
- ASn = 29
- Healthy controlsn = 43reference
- Outcome
- Contents of the faecal microbiota
Main finding
As reported in the abstract
Faecal microbiota composition
- Substantial clustering based upon diagnosis
- Decreased richness in AS patients; measures of evenness similar
- Faecalibacterium prausnitzii and Coprococcus elevated in AS vs controls (after correction for multiple comparisons), even when restricted to female subjects
- Bacteroides fragilis, Ruminococcus and Akkermansia muciniphila depleted in AS
- After correction for multiple comparisons
Observational data: associations, not effects.
Original publication
The faecal microbiota is distinct in HLA-B27+ ankylosing spondylitis patients versus HLA-B27+ healthy controls. Clin Exp Rheumatol. Published 12 May 2022. doi:10.
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