Spondyloarthritis & psoriatic arthritis
Anatomical variation of the sacroiliac joint carries an increased risk for erosion and bone marrow oedema in axial spondyloarthritis
Authors' conclusion
Joint form variations are associated with the presence of inflammatory lesions on SI joint MRIs of axSpA patients.
Study context
- Population
- Patients from four prospective cohorts with sufficient SI joint MRI dataof 1194 evaluated
- Participants
- 684 patients
- Exposure
- Atypical vs typical SI joint forms in axial spondyloarthritis (axSpA) and controls
- axSpAn = 379
- Controlsn = 305reference
- Outcome
- Association of SI joint form variations with inflammatory lesions (erosion, sclerosis, fat metaplasia, bone marrow oedema (BMO)) on SI joint MRI
Methodological detailsfour prospective cohorts, two independent readers, logistic regression
- Four prospective cohorts
- Two independent readers
- Logistic regression
Main finding
As reported in the abstract
Intra-articular variants (axSpA)Odds ratio (95% CI)
Erosions
2.09(1.18–3.69)
BMO
1.79(1.13–2.82)
Observational data: associations, not effects.
Further findings
Atypical joint forms (prevalence)
Intra-articular variants (prevalence)
P < 0.001
Accessory joints and lesions
| OR (95% CI) | ||
|---|---|---|
| Accessory joints (axSpA)Sclerosis | 2.54 (1.10–5.84) | |
| Accessory joints (Controls)Sclerosis | 17.91 (6.92–46.37) | |
| Accessory joints (Controls)BMO | 2.05 (1.03–4.07) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | axSpA | Controls | P value |
|---|---|---|---|
| Crescent joint shape (prevalence) | 11.0% | 5.3.% | P < 0.001 |
- Atypical joint forms (prevalence): 154/354 and 134/303
Original publication
Anatomical variation of the sacroiliac joint carries an increased risk for erosion and bone marrow oedema in axial spondyloarthritis. Rheumatology (Oxford). Published 9 May 2022. doi:10.
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