Sjögren's disease & overlap diseases

The contribution of salivary gland ultrasound to juvenile Sjögren disease classification: performance of a weighted scoring model

Rheumatology (Oxford)Published Diagnostic accuracy study

Authors' conclusion

Although the inclusion of US in the classification model did not significantly improve overall discrimination, it enhanced specificity and PPV, particularly in borderline cases.

Study context

Population
Patients with juvenile Sjögren's disease (jSjD) with B-mode parotid US at diagnosis
Participants
17 patients
Comparison
Weighted scoring model including parotid US vs 2016 ACR/EULAR classic model (without US)
Outcome
Performance of the WS for predicting ACR/EULAR classification (≥4)
Methodological detailsretrospective, ROC analysis
  • Retrospective
  • ROC analysis

Performance

As reported in the abstract

Prediction of fulfilment of ACR/EULAR classification criteria
Test or modelAUC
Weighted scoring (WS)0.72

Weighted scoring (WS)

AUC0.72

Further findings

OutcomeWSCMP value
Classification performance, WS vs CMComparable overall performanceP = 0.76
AUC0.850.87
Specificity92%77%
PPV86%73%
US alone for identifying patients fulfilling ≥2 conventional items (composite score ≥2)
0.84 · AUC

Original publication

The contribution of salivary gland ultrasound to juvenile Sjögren disease classification: performance of a weighted scoring model. Rheumatology (Oxford). Published 9 December 2025. doi:10.1093/rheumatology/keaf660

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