Lupus & antiphospholipid syndrome
The complement system is linked to insulin resistance in patients with systemic lupus erythematosus
Authors' conclusion
IR and metabolic syndrome are positively and independently related to higher serum levels of some serum C elements in patients with SLE with a predominant role of the alternative pathway elements.
Study context
- Population
- Non-diabetic patients with systemic lupus erythematosus (SLE)non-diabetic
- Participants
- 225 patients
- Outcome
- Relationship between C system (functional assays of three pathways; serum C1q, C2, C3, C4, factor D, C3a, C1 inhibitor, factor H) and IR indices (homeostatic model assessment (HOMA)) and presence of metabolic syndrome
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
- Serum C3a and factor H levels positively related to higher HOMA2-IR index, after adjustment for covariates incl. traditional CV risk factors associated with insulin resistance (IR) and prednisone
- Serum C1q and C3 associated with higher OR for presence of metabolic syndrome, after multivariable adjustment for covariates
Observational data: associations, not effects.
Original publication
The complement system is linked to insulin resistance in patients with systemic lupus erythematosus. Clin Exp Rheumatol. Published 22 May 2023. doi:10.
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