Lupus & antiphospholipid syndrome
Four trajectories of 24-hour urine protein levels in real-world lupus nephritis cohorts
Authors' conclusion
Four trajectories of LN shed some light to guide the management of LN and further clinical trials design.
Study context
- Population
- Two lupus nephritis (LN) cohorts that underwent renal biopsies at Renji Hospital, receiving standard of care in a real-world settingderivation cohort
- Participants
- 194 participants
- Exposure
- Four 24hUP trajectories: Rapid Responders vs Good Responders vs Suboptimal Responders vs Non-Responders
- Outcome
- Trajectory patterns of 24hUP (latent class mixed modelling (LCMM))
Methodological detailslatent class mixed modelling, multinomial logistic regression, derivation and validation cohorts, nomogram development
- Latent class mixed modelling
- Multinomial logistic regression
- Derivation and validation cohorts
- Nomogram development
Main finding
As reported in the abstract
KDIGO renal complete remission rate (time to complete remission, months) by trajectory
| Group | Value | Time to complete remission, months |
|---|---|---|
| Rapid Responders | 84.2% | 4.19 |
| Good Responders | 79.6% | 7.94 |
| Suboptimal Responders | 40.4% | not applicable |
| Non-Responders | 9.8% | not applicable |
Value
Rapid Responders84.2%
Good Responders79.6%
Suboptimal Responders40.4%
Non-Responders9.8%
Time to complete remission, months
Rapid Responders4.19
Good Responders7.94
Suboptimal Respondersnot applicable
Non-Respondersnot applicable
- Difference across four trajectories
- P < 0.001
Observational data: associations, not effects.
Further findings
Nomogram predicting Rapid Responders (age, SLE duration, albumin, 24hUP)
- C-indices
- >0.85
Nomogram predicting Good Responders (gender, new-onset LN, glomerulosclerosis, partial remission within 6 months)
- C-indices
- 0.73~0.78
Validation cohort (117 patients, 500 study visits)
- Nomograms effectively sorted out 'Rapid Responders' and 'Good Responders'
Original publication
Four trajectories of 24-hour urine protein levels in real-world lupus nephritis cohorts. RMD Open. Published 19 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →