Lupus & antiphospholipid syndrome
Cognitive dysfunction in patients with systemic lupus erythematosus. A cross-sectional study in a Brazilian sample
Authors' conclusion
According to the MoCA, visuospatial cognition and abstraction were impaired, and according to the MMSE, spatial orientation and language were impaired in patients with SLE. The CD was correlated with cumulative damage and disease activity.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and controls, Brazilian sample
- Participants
- 103 vs 95
- Exposure
- SLE vs controls
- SLEn = 103
- Controlsn = 95reference
- Outcome
- Cognitive performance (MoCA and MMSE)
Methodological detailscontrolled
- Controlled
Main finding
As reported in the abstract
Cognitive performance (MoCA, MMSE)
- SLE vs Controls: P = 0.009
- SLE vs Controls: P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| MoCA domains impaired in SLE vs controlsSLE vs Controls · visuospatial | P = 0.03 |
| MoCA domains impaired in SLE vs controlsSLE vs Controls · abstraction | P = 0.002 |
| MMSE domains reduced in SLE vs controlsSLE vs Controls · language | P = 0.002 |
| MMSE domains reduced in SLE vs controlsSLE vs Controls · spatial orientation | P = 0.01 |
Correlations of cognitive scores with damage and disease activity (SLE)
- MoCA vs SLICC/ACR/DI, r
- −0.29
- MMSE vs SLICC/ACR/DI, r
- −0.21
- MoCA vs SLEDAI, r
- −0.22
Associations with cumulative GC dose, depression, clinical or serological profile
- No associations found
Original publication
Cognitive dysfunction in patients with systemic lupus erythematosus. A cross-sectional study in a Brazilian sample. Lupus. Published 19 May 2023. doi:10.
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