Lupus & antiphospholipid syndrome
Aquaporin-4 IgG antibodies: predictors of positivity and their relationship with neuropsychiatric disorders and white matter lesions in Juvenile systemic lupus erythematosus
Authors' conclusion
jSLE patients with higher severity scores, neurological disorders, or white matter lesions could develop antibodies against AQP4.
Study context
- Population
- Patients with juvenile SLE (juvenile systemic lupus erythematosus (jSLE))
- Participants
- 90 patients
- Exposure
- AQP4-Ab positive vs AQP4-Ab negative jSLE patients
- AQP4-Ab positiven = 56
- Outcome
- Prevalence and predictors of AQP4-Ab positivity in jSLE
Main finding
As reported in the abstract
AQP4-Ab positivity
AQP4-Ab positive
62.2%
56
Observational data: associations, not effects.
Further findings
Clinical features, AQP4-Ab positive vs negative
- Higher disease activity scores
- P < 0.001
- Discoid lesions
- P = 0.039
- Neurological disorders
- P = 0.001
- Psychosis
- P = 0.009
- Seizures
- P = 0.032
- Renal involvement
- P = 0.004
- Cardiac involvement
- P = 0.013
- Lower C3 levels
- P = 0.006
- All more likely in AQP4-Ab positive
MRI white matter lesions, AQP4-Ab positive vs negative
- White matter hyperintensities
- P = 0.008
- White matter atrophy
- P = 0.03
- More likely in AQP4-Ab positive
Treatments received, AQP4-Ab positive vs negative
- CYC
- P = 0.028
- Antiepileptic drugs
- P = 0.032
- Plasma exchange therapy
- P = 0.049
- More likely in AQP4-Ab positive
Original publication
Aquaporin-4 IgG antibodies: predictors of positivity and their relationship with neuropsychiatric disorders and white matter lesions in Juvenile systemic lupus erythematosus. Pediatr Rheumatol Online J. Published 19 May 2023. doi:10.
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