Lupus & antiphospholipid syndrome
The impact of white matter brain lesions on processing speed deficits in systemic lupus erythematosus patients
Study context
- Population
- Patients diagnosed with systemic lupus erythematosus (SLE)
- Participants
- 33 patients
- Exposure
- SLE patients with white matter lesions (WMLs) vs without WMLs
- WMLsn = 15
- Without WMLsn = 18reference
- Outcome
- Relationship between presence of WMLs and cognitive dysfunction (psychometric scores)
Methodological details3 T brain magnetic resonance imagining (MRI), Automated Neuropsychological Assessment Metrics (ANAM) and standard pen and paper neuropsychological tests, Freesurfer 5.3 volumetric segmentation
- 3 T brain MRI
- ANAM and standard pen and paper neuropsychological tests
- Freesurfer 5.3 volumetric segmentation
Main finding
As reported in the abstract
Psychometric scores
- Patients with WMLs showed deficits in attention and executive functions, as well as memory deficits vs patients without WMLs (STROOP, Color Trail Test (CTT), Californian Verbal Learning Test (CVLT); ANAM: Procedural Reaction Time (PRT), CS_D, Spatial Processing (SP), Tower Puzzle (TP), 2CHRT, RM CPT, Mat GR, Go/No_Go Go)
Observational data: associations, not effects.
Further findings
Structural brain volumes (Freesurfer 5.3)
- Significant differences in right choroid plexus, left choroid plexus and right lateral ventricle volumes; all greater in patients with WMLs
Original publication
The impact of white matter brain lesions on processing speed deficits in systemic lupus erythematosus patients. Lupus. Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →