Lupus & antiphospholipid syndrome
Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort
Main finding · Damage accrual (SDI)Result — go to the resultIncidence rate ratio 1.645 95% CI 1.187–2.280Authors' conclusion
Hypertension was associated with subsequent greater damage in our SLE patients.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients of the Almenara Lupus Cohort, January 2012 to January 2020 (93% women)
- Participants
- 314 patients1,695 visits
- Exposure
- Hypertension vs no hypertension
- Outcome
- Damage accrual (SLICC/ACR DI)
Methodological detailsgeneralized estimating equations, multivariable analysis adjusted for demographic, disease-related factors and treatment
- Generalized estimating equations
- Multivariable analysis adjusted for demographic, disease-related factors and treatment
Main finding
Damage accrual (SDI)
Incidence rate ratio
1.645
95% CI 1.187–2.280
P = 0.003
Hypertensionvs No hypertension
IRR 1.645 (95% CI 1.187–2.280); P = 0.003
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Renal damage (per-domain analysis)Multivariable model | 4.331 (1.547–12.126) | P = 0.005 | |
| 0.050.21520Odds ratio (log scale) |
Prevalence of hypertension at least once during follow-up
- Prevalence of hypertension
- 56.4%
Baseline damage (SDI) at first visit and increase at subsequent visit
- Baseline SDI, mean (SD)
- 0.8 (SD: 1.2)
- Increase at subsequent follow-up visit (SD)
- 0.15 (SD: 0.46)
Original publication
Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort. Lupus. Published 8 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →