Lupus & antiphospholipid syndrome
Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis
Authors' conclusion
The effectiveness of belimumab was reproducible in Chinese patients with active LN.
Study context
- Population
- Patients with active lupus nephritis (LN), 24-hour urine protein≥1 g and eGFR≥30 mL/min/1.73 m² at baseline, receiving intravenous belimumab add-on; Chinese patients117 analysed at 6 months
- Participants
- 122 patients
- Outcome
- Renal response (CRR, PRR, NRR, PERR); predictors of NRR
- Follow-up
- 6 months
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
Renal response at 6 months
| Group | Complete renal response (CRR) | Partial renal response (PRR) | No renal response (NRR) | Primary efficacy renal response (PERR) |
|---|---|---|---|---|
| Belimumab | 35.9% | 17.1% | 47.0% | 44.4% |
Belimumab
Complete renal response (CRR)35.9%
Partial renal response (PRR)17.1%
No renal response (NRR)47.0%
Primary efficacy renal response (PERR)44.4%
Observational data: associations, not effects.
Further findings
Predictor of NRR6: anti-SSA/Ro60 positivity · 6 months
| OR (95% CI) | P value | ||
|---|---|---|---|
| anti-SSA/Ro60Multivariable logistic regression | 3.16 (1.14–8.74) | P = 0.027 | |
| 0.10.31310Odds ratio (log scale) |
Renal response rates · 12 months (n=72)
- CRR
- 55.6%
- PRR
- 19.4%
- NRR
- 26.4%
- PERR
- 58.3%
Proteinuria, daily prednisone dosage and SLEDAI-2K scores significantly decreased · 6 and 12 months
- Significant decrease at 6 and 12 months
- P < 0.0001
Predictor of CRR at 12 months
- NRR6 was the strongest negative predictor of CRR at 12 months
Anti-SSA/Ro60 and anti-dsDNA serotype combination
- Combination quantitatively predicted belimumab renal response
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis. Lupus Sci Med. Published 28 May 2024. doi:10.
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