Lupus & antiphospholipid syndrome
Evaluating the metabolic score for insulin resistance in patients with systemic lupus erythematosus
Authors' conclusion
In patients with SLE, METS-IR remains associated with cardiometabolic parameters, including lipid profile and insulin resistance. However, disease-specific factors such as disease activity and accumulated damage show no association with METS-IR.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE)
- Participants
- 308 patients
- Outcome
- Association of METS-IR with disease characteristics and cardiovascular comorbidities
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
Associations of METS-IR
- Metabolic Score for Insulin Resistance (METS-IR) not associated with SLE disease duration, activity or damage
- CRP and anticardiolipin IgG and anti-beta2 glycoprotein I IgG positivity independently associated with higher METS-IR after multivariable analysis
- Apolipoprotein B and A1 levels and atherogenic index significantly positively associated with METS-IR after adjustment
- Higher serum insulin, C-peptide and HOMA-derived insulin resistance and beta cell function positively and significantly correlated with elevated METS-IR
Observational data: associations, not effects.
Original publication
Evaluating the metabolic score for insulin resistance in patients with systemic lupus erythematosus. Clin Exp Rheumatol. Published 29 May 2025. doi:10.
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