Lupus & antiphospholipid syndrome
Rheumatologic Manifestations of Patients With Type B Insulin Resistance
Authors' conclusion
TBIR can be a rare complication of SLE, is associated with the presence of high-titer U1 RNP autoantibodies, and may co-occur with other rare SLE manifestations.
Study context
- Population
- Patients with type B insulin resistance (TBIR) (autoantibodies inhibiting the insulin receptor) seen at the National Institutes of Health, 1976–2024
- Participants
- 38 patients
- Outcome
- Laboratory and clinical features associated with TBIR, incl. SLE manifestations (hypocomplementemia, cytopenias, autoantibody seropositivity)
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
As reported in the abstract
Clinical and laboratory features of TBIR
- SLE as underlying diagnosis
- 81.5%
- Sjögren disease; primary biliary cholangitis
- one patient each
- Female
- 89.5%
- Black/African American
- 84.2%
- SLEDAI-2K, median (IQR)
- 14 (7)
- High or very high U1 RNP autoantibodies
- >50%
- Acute neuropathies of 7th and/or 8th cranial nerve
- 18.4%
- Angioedema
- 10.5%
- Uveitis
- 5%
Observational data: associations, not effects.
Original publication
Rheumatologic Manifestations of Patients With Type B Insulin Resistance. Arthritis Care Res (Hoboken). Published 6 March 2026. doi:10.
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