Lupus & antiphospholipid syndrome
Progression from at-risk state to clinical and severe systemic lupus erythematosus involves molecular dysregulations potentially reversible by biologics: implications for early diagnosis and treatment
Authors' conclusion
IFN-α/γ and inflammatory cytokine signatures characterise evolving/early SLE, whereas amplification of IFN signalling and oxidative phosphorylation denotes severity.
Study context
- Population
- Individuals with nondiagnostic features suggestive of systemic lupus erythematosus (SLE); independent at-risk validation cohort (n = 15 progressors, n = 20 nonprogressors)
- Exposure
- Progressors vs nonprogressors, compared with healthy and early SLE
- Outcome
- Transcriptomic changes during progression to SLE
Methodological detailsmulticentre, blood RNA-sequencing, external validation cohort
- Multicentre
- Blood RNA-sequencing
- External validation cohort
Main finding
As reported in the abstract
17-gene susceptibility signature predicted transition in the external cohort
AUC 0.80
95% CI 0.65–0.94
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Progression from at-risk state to clinical and severe systemic lupus erythematosus involves molecular dysregulations potentially reversible by biologics: implications for early diagnosis and treatment. Ann Rheum Dis. Published 5 March 2026. doi:10.
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