Lupus & antiphospholipid syndrome
High incidence of herpes zoster among systemic lupus erythematosus (SLE) patients in Indonesia: a retrospective cohort study
Authors' conclusion
The incidence of HZ in this Southeast Asian SLE cohort was high, particularly in patients with recent diagnoses and those receiving mycophenolate.
Study context
- Population
- Adult SLE patients with at least 6 months of follow-up, allergy-immunology outpatient clinic of a tertiary referral centre in Indonesia
- Participants
- 130 patients733 person-years
- Outcome
- Incidence and clinical risk factors of HZ
Methodological detailssingle-centre, tertiary referral centre, systematic random sampling, multivariate binomial regression
- Single-centre
- Tertiary referral centre
- Systematic random sampling
- Multivariate binomial regression
Main finding
As reported in the abstract
HZ incidence · median follow-up 5.6 years
Cumulative incidence of herpes zoster (HZ)
16.5%
21/130 patients
Incidence rate per 1000 person-years
28.7
Observational data: associations, not effects.
Further findings
Independent risk factors for HZ (multivariate analysis)
| RR (95% CI) | P value | ||
|---|---|---|---|
| Disease duration ≤1 year | 3.23 (1.58–6.63) | P = 0.001 | |
| Mycophenolate use | 3.23 (1.18–8.87) | P = 0.023 | |
| 0.10.31310Relative risk (log scale) |
- Corticosteroid dose and comorbidities not significantly associated with HZ
Original publication
High incidence of herpes zoster among SLE patients in Indonesia: a retrospective cohort study. Lupus Sci Med. Published 3 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →