Autoinflammatory & rare systemic diseases
The comparison of clinical and pathological features between patients of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with different microbiological findings in bone biopsy
Authors' conclusion
NGS and bacterial culture expand the variety of detectable bacteria and improve the detection rate of bacteria in SAPHO syndrome.
Study context
- Population
- Patients diagnosed with SAPHO syndrome undergoing CT-guided percutaneous bone punctureSAPHO syndrome
- Participants
- 34 patients
- Exposure
- Bacteria-positive vs bacteria-negative SAPHO syndrome; SAPHO syndrome vs infectious suppurative osteomyelitis (pathology)
- Infectious suppurative osteomyelitisn = 32
- Outcome
- Bacterial positive rate in bone biopsy
Methodological detailsCT-guided percutaneous bone biopsy, next-generation sequencing (NGS) and microbiological culture
- CT-guided percutaneous bone biopsy
- NGS and microbiological culture
Main finding
As reported in the abstract
Positive rate of bacteria by NGS and by bacterial culture, respectively
41.2%
Observational data: associations, not effects.
Further findings
Clinical symptoms, biochemical markers, imaging and pathological findings
- Differences not statistically significant between bacteria-positive and bacteria-negative groups
Pathology: SAPHO syndrome vs infectious suppurative osteomyelitis
- SAPHO syndrome had less inflammatory cell infiltration and increased granulation tissue formation
Original publication
The comparison of clinical and pathological features between patients of SAPHO syndrome with different microbiological findings in bone biopsy. Clin Exp Rheumatol. Published 18 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →