Autoinflammatory & rare systemic diseases
TNF-alpha blockade in primary chronic non-bacterial osteomyelitis of the mandible
Authors' conclusion
Our results suggest that blocking TNF-α is efficient and safe in CNOM.
Study context
- Population
- Patients with refractory primary chronic non-bacterial osteomyelitis of the mandible (CNOM) and high disease burden referred to one centre10 received anti-TNF-α
- Participants
- 15 patients
- Outcome
- Response to TNF-α blockade
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Rapid and sustained remission in a majority of patients
- Treatment tapered and stopped without relapse in some patients
- Male sex seems associated with a poorer outcome
Observational data: associations, not effects.
Safety
- No serious adverse events
Original publication
TNF-alpha blockade in primary chronic non-bacterial osteomyelitis of the mandible. Rheumatology (Oxford). Published 23 July 2024. doi:10.
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