Autoinflammatory & rare systemic diseases
Mapping the infectious burden in VEXAS syndrome: a systematic review and rationale for prevention
Authors' conclusion
We included 57 studies (813 patients) showing that infections in patients with VEXAS syndrome were frequent, severe in 40-60% of cases, and fatal in 6-15% of cases.
Study context
- Population
- Patients with VEXAS syndrome
- Participants
- 813 patients57 studies
- Outcome
- Infectious burden of VEXAS syndrome
Pooled result
As reported in the abstract
Infections in VEXAS syndrome
Severe infections
40-60%
Fatal infections
6-15%
Further pooled results
- Opportunistic pathogens (Pneumocystis jirovecii, Legionella pneumophila, non-tuberculous mycobacteria, varicella zoster virus) frequently reported, even in patients not receiving immunosuppressive therapy
Original publication
Mapping the infectious burden in VEXAS syndrome: a systematic review and rationale for prevention. Lancet Rheumatol. Published 4 September 2025. doi:10.
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