Autoinflammatory & rare systemic diseases
Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases
Authors' conclusion
The HRQOL among adults with SAPHO-CNO is low, with more than half of patients experiencing greater impact on perceived pain, difficulty performing usual activities, and feelings of anxiety or depression.
Study context
- Population
- Adults with SAPHO-CNO enrolled in the first US-based prospective registry; mean age 37.7 (SD 15.0) years, mean disease duration 6.4 (SD 6.2) years
- Participants
- 138 adults
- Outcome
- Health-related quality of life (HRQOL) by EQ-5D index and EQ-5D VAS
Methodological detailsfirst US-based SAPHO-CNO registry, focused scoping review of EQ-5D outcomes in similar diseases
- First US-based SAPHO-CNO registry
- Focused scoping review of EQ-5D outcomes in similar diseases
Main finding
As reported in the abstract
HRQOL (5-level EQ-5D index; EQ-VAS)
- Pain/discomfort
- 86%
- Difficulty in carrying out usual activities
- 65%
- Anxiety/depression
- 54%
- Problems in all 5 EQ-5D domains
- over one-third
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases. J Rheumatol. Published 1 August 2025. doi:10.
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