Autoinflammatory & rare systemic diseases
HLA-B*27 is associated with chronic nonbacterial osteomyelitis (CNO) in a European cohort
Main finding · HLA-B*27 frequencyResult — go to the resultCombined OR 2.2Authors' conclusion
Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.
Study context
- Population
- 3 European CNO populations and local control populations3 European cohorts
- Participants
- 572 vs 33,256
- Comparison
- CNO cases vs local control populations
- CNO casesn = 572
- Controlsn = 33,256reference
- Outcome
- HLA-B*27 frequency (risk of developing CNO)
Methodological detailsmulticentre (3 European CNO populations), meta-analysis of odds ratios (fixed effects model), Fisher's exact test with Bonferroni correction
- Multicentre (3 European CNO populations)
- Meta-analysis of odds ratios (fixed effects model)
- Fisher's exact test with Bonferroni correction
Main finding
HLA-B*27 frequency
Combined OR
2.2
P = 3 × 10-11
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| HLA-B*27 association, male vs female cases (subgroup) | 1.99 | corrected p-value = 0.015 |
HLA-B*27 and co-occurrence of psoriasis, arthritis or inflammatory bowel disease
- HLA-B*27 status not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease
Original publication
HLA-B*27 is associated with CNO in a European cohort. Pediatr Rheumatol Online J. Published 5 June 2023. doi:10.
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