Autoinflammatory & rare systemic diseases
Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis
Authors' conclusion
Timely diagnosis is challenging and mainly follows from increased isotope uptake on nuclear examination. Biopsies, autoantibodies and HLA status are non-contributory, and biochemical inflammation only variably detected.
Study context
- Population
- Adult patients with CNO of the anterior chest wall (sternocostoclavicular hyperostosis, sternocostoclavicular hyperostosis (SCCH))40 studies
- Outcome
- Clinical presentation (aim 1) and therapeutic modalities (aim 2) in adult CNO/SCCH
Methodological detailsrandom effects model, double-arcsine transformed proportional data
- Random effects model
- Double-arcsine transformed proportional data
Pooled result
As reported in the abstract
Clinical presentation, pooled proportions
- Female
- 67% (95% CI 60, 73)
- Diagnostic delay
- 5 years (95% CI 3, 7)
- Chest pain
- 89% (95% CI 79, 96)
- Swelling
- 79% (95% CI 62, 91)
- Pustulosis palmoplantaris
- 53% (95% CI 37, 68)
- Arthritis
- 24% (95% CI 11, 39)
- Acne
- 8% (95% CI 4, 13)
- Increased isotope uptake
- 99% (95% CI 96, 100)
Further pooled results
Good treatment response (aim 2)
- Pamidronate
- 83% (95% CI 60, 98)
- Biologicals
- 56% (95% CI 26, 85)
Original publication
Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis. Rheumatology (Oxford). Published 12 August 2022. doi:10.
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