Autoinflammatory & rare systemic diseases
Evolution of bone lesions in adults with chronic nonbacterial osteitis (CNO): A long-term follow-up study
Authors' conclusion
The development of new bone lesions in treated adult CNO patients is typically confined to previously affected regions, primarily the anterior chest wall. Progression of structural changes occurs in the majority of patients after longer follow-up.
Study context
- Population
- Confirmed adults with CNO treated at the Dutch national CNO referral centre, 1992–2023mean follow-up 6.1 ± 5.2 years
- Participants
- 182 adults
- Outcome
- Incidence rates (IRs) for new lesions, progression and regression of existing lesions
Methodological detailssingle referral centre, long-term follow-up, Poisson method, Kaplan-Meier
- Single referral centre
- Long-term follow-up
- Poisson method
- Kaplan-Meier
Main finding
As reported in the abstract
New lesions, IR per 100 person-years
4
95% CI 3–5
Progression, IR per 100 person-years
7
95% CI 6–9
Regression, IR per 100 person-years
1
95% CI 0.3.-1
Observational data: associations, not effects.
Further findings
Lesion outside anterior chest wall in patients with anterior chest wall involvement only (n = 147)
- Patients developing a lesion outside this area
- 1
- IR (0.06-1)
- 0.3
Cumulative incidence of new lesion development · 2, 5 and 10 years
%
- At 2 years (0-5)
- 2
- At 5 years (5-17)
- 11
- At 10 years (23-48)
- 36
Cumulative incidence of progression · 2, 5 and 10 years
%
- At 2 years (3-10)
- 7
- At 5 years (20-36)
- 29
- At 10 years (43-64)
- 56
Sole involvement of the anterior chest wall (most common pattern)
- Proportion of patients
- 84 %
Associations between baseline clinical characteristics and outcomes
- No associations found
Original publication
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