Autoinflammatory & rare systemic diseases
Axial bone involvement in sarcoidosis has a good prognosis: Longitudinal study of a cohort of 48 patients
Authors' conclusion
This longitudinal evaluation over a 3-year period, combining clinical, radiological, and biochemical data, shows that sarcoidosis axial bone lesions have a favorable prognosis.
Study context
- Population
- Patients with histologically confirmed sarcoidosis and axial bone involvement
- Participants
- 48 patients
- Exposure
- Follow-up vs baseline MRI and positron emission tomography (PET)
- Outcome
- Prognosis of axial bone lesions (reduction or resolution on serial MRI and PET vs baseline)
Methodological detailsserial MRI and PET imaging
- Serial MRI and PET imaging
Main finding
As reported in the abstract
Significant reduction or resolution of bone lesions vs baseline
MRI
19.5
PET
68.3 %
MRI: P < 0.01 · PET: P < 0.001
Observational data: associations, not effects.
Further findings
No corresponding bone lesions on CT (PET-identified multifocal bone involvement)
- Cases without CT-detected lesions
- 80.8 %
Bone pain during follow-up
- Bone pain improved significantly
- P = 0.01
- Association with favourable PET changes
- P = 0.02
- Association with favourable MRI changes
- P = 0.04
Bone relapse
- Patients with bone relapse
- 7
Safety
- No epiduritis or soft-tissue infiltration was observed
Original publication
Axial bone involvement in sarcoidosis has a good prognosis: Longitudinal study of a cohort of 48 patients. Semin Arthritis Rheum. Published 5 February 2025. doi:10.
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