Autoinflammatory & rare systemic diseases
Spectrum and significance of 18F-FDG-PET/CT abnormalities in VEXAS syndrome
Authors' conclusion
18F-FDG-PET/CT imaging reveals frequent but non-specific abnormalities in VEXAS syndrome, with persistent bone marrow hypermetabolism suggesting subclinical disease activity.
Study context
- Population
- Patients with genetically-confirmed VEXAS syndrome who underwent 18F-FDG-PET/CT imaging
- Participants
- 66 patients125 scans
- Exposure
- Active disease vs Remission
- Outcome
- Sites of abnormal FDG uptake
Methodological detailsmulticentre, observational, Qualitative interpretations based on local nuclear medicine reports
- Multicentre
- Observational
- Qualitative interpretations based on local nuclear medicine reports
Main finding
As reported in the abstract
Bone marrow
83%
Lymph nodes
53%
Pulmonary involvement
38%
Vascular involvement
11%
Observational data: associations, not effects.
Further findings
Number of organs with abnormal FDG uptake, active disease vs remission
P < 0.001
Scans during presumed clinical remission with persistent abnormalities
- Persistent abnormalities
- 90%
- Bone marrow
- 57%
Original publication
Spectrum and significance of 18F-FDG-PET/CT abnormalities in VEXAS syndrome. Rheumatology (Oxford). Published 17 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →