Autoinflammatory & rare systemic diseases
Clinical significance of serum immunoglobulin E (IgE)/IgG4 ratio in patients with IgG4-related disease
Authors' conclusion
Although the serum IgE/IgG4 ratio did not correlate with baseline disease activity, it was independently associated with remission at 1 year.
Study context
- Population
- Patients with newly diagnosed IgG4-related disease (IgG4-RD) with data on both serum IgG4 and IgE levels
- Participants
- 32 patients
- Outcome
- Association of serum IgE/IgG4 ratio with remission (IgG4-RD RI score of 0)
- Follow-up
- 1 year
Methodological detailsmultivariable logistic regression, Spearman's correlation
- Multivariable logistic regression
- Spearman's correlation
Main finding
As reported in the abstract
Remission at 1 year, per higher IgE/IgG4 ratio
Higher IgE/IgG4 ratio independently associated with remission at 1 year, aOR
1.052
95% CI 1.008–1.099p=0.021
Observational data: associations, not effects.
Further findings
Baseline serum levels, median (range as printed)
- IgG4, median (1985.0-14075.0) mg/L
- 5090.0
- IgE, median (93.9-791.8) kU/L
- 312.5
- IgE/IgG4 ratio, median (0.015-0.104)
- 0.052
Correlation with IgG4-RD responder index (RI) (Spearman)
- Serum IgG4, rho (p<0.001)
- 0.628
- IgE, rho (p=0.249)
- 0.210
- IgE/IgG4 ratio, rho (p=0.165)
- −0.251
Original publication
Clinical significance of serum IgE/IgG4 ratio in patients with IgG4-related disease. Clin Exp Rheumatol. Published 1 August 2025. doi:10.
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