Autoinflammatory & rare systemic diseases
Urological manifestations in familial Mediterranean fever excluding renal amyloidosis: a systematic review
Authors' conclusion
Our study results show that acute scrotum and epididymo-orchitis were the most frequent urological manifestations in FMF, and testicular amyloidosis and fertility impairment were also notable.
Study context
- Population
- FMF patients with a confirmed urological pathology, excluding renal amyloidosis-related involvement
- Participants
- 2,040 patients38 studies
- Outcome
- Spectrum of urological manifestations and fertility outcomes
Methodological detailsPRISMA 2020, descriptive statistics, Mean ± SD age 23.35 ± 16 years; 43.2% female, Searched PubMed, Web of Science, Google Scholar and Cochrane Library up to 4 July 2025; 14 case reports, 10 case series, 10 cross-sectional and 4 cohort studies
- PRISMA 2020
- Descriptive statistics
- Mean ± SD age 23.35 ± 16 years; 43.2% female
- Searched PubMed, Web of Science, Google Scholar and Cochrane Library up to 4 July 2025; 14 case reports, 10 case series, 10 cross-sectional and 4 cohort studies
Pooled result
As reported in the abstract
Urological manifestations in FMF
- Acute scrotum, n (75% recurrence)
- 64
- Testicular amyloidosis (biopsy-confirmed), n
- 40
- Epididymo-orchitis, n (fever in 84%)
- 25
- Testicular torsion, n
- 4
- Hydrocele, n
- 4
- Bladder amyloidosis, n
- 2
Further pooled results
Semen analyses (189 reported)
- Azoospermia
- 26.9%
- Oligospermia
- 14.8%
- Infertility reported in patients with testicular amyloidosis
Original publication
Urological manifestations in familial Mediterranean fever excluding renal amyloidosis: a systematic review. Rheumatology (Oxford). Published 24 March 2026. doi:10.
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