Autoinflammatory & rare systemic diseases
Long-term rheumatologic comorbidities in familial Mediterranean fever
Main finding · Composite of any prespecified rheumatologic or autoimmune diagnosisResult — go to the resultAdjusted odds ratio 2.18Authors' conclusion
FMF is associated with a selective, persistent excess of rheumatologic and autoimmune diseases despite colchicine, supporting long-term rheumatologic surveillance.
Study context
- Population
- Patients with confirmed Familial Mediterranean fever (FMF) and matched controls, Leumit Health Services, Israel (2001–2024); mean age 24.5 years; 51% femalematched cohort
- Participants
- 3,324 vs 13,296
- Exposure
- FMF vs matched controls
- FMFn = 3,324
- Controlsn = 13,296reference
- Outcome
- Composite of:
- Any prespecified rheumatologic
- Autoimmune diagnosis
- Follow-up
- Up to 20 years
Methodological detailsnationwide, population-based, matched 1:4 by age, sex and socioeconomic status, 12-month washout, multivariable logistic regression, false discovery rate correction
- Nationwide
- Population-based
- Matched 1:4 by age, sex and socioeconomic status
- 12-month washout
- Multivariable logistic regression
- False discovery rate correction
Main finding
As reported in the abstract
Adjusted odds ratio
2.18
By group
Observational data: associations, not effects.
Further findings
Amyloidosis
q < 0.001
| Outcome | aOR | P value |
|---|---|---|
| Comorbidities during follow-up: AS, lupus, vasculitis, PsA and Crohn's diseaseRange across diseases | 1.31-12.7 | all q < 0.05 |
Baseline comorbidities
- FMF associated with BD, RA, FM, gout, OA and connective tissue disease (all q < 0.05)
Original publication
Long-term rheumatologic comorbidities in familial Mediterranean fever. Semin Arthritis Rheum. Published 3 June 2026. doi:10.
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