Autoinflammatory & rare systemic diseases
Increased risk for stroke in patients with familial Mediterranean fever: results from a large population-based study
Main finding · StrokeResult — go to the resultCrude hazard ratio 1.42 95% CI 1.15–1.76Authors' conclusion
FMF patients are at increased risk for stroke regardless of known complications.
Study context
- Population
- FMF patients diagnosed 2000–2016 and matched controls, Clalit Health Services database, Israel; mean age at start of follow-up 25.7 yearsmedian follow-up 12.5 years
- Exposure
- FMF vs matched controls from the general population
- FMFn = 9,769
- Outcome
- Incidence and risk of stroke
Methodological detailspopulation-based, matched on age, gender and place of residence, univariate and multivariate models adjusting for cardiovascular risk-factors
- Population-based
- Matched on age, gender and place of residence
- Univariate and multivariate models adjusting for cardiovascular risk-factors
Main finding
Stroke
Crude hazard ratio
1.42
95% CI 1.15–1.76
P < 0.001
Events by group
FMFvs Controls
crude HR 1.42 (95% CI 1.15–1.76); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Stroke by FMF complications (multivariate analysis)FMF with amyloidosis with related or non-related renal failurevs Controls | 2.16 (1.38–3.38) | P < 0.001 | |
| Stroke by FMF complications (multivariate analysis)FMF without these complicationsvs Controls | 1.32 (1.04–1.67) | P < 0.05 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Increased risk for stroke in patients with familial Mediterranean fever: results from a large population-based study. Rheumatology (Oxford). Published 2 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →