Autoinflammatory & rare systemic diseases
The association between familial Mediterranean fever and incident cirrhosis: A population-based matched cohort study
Main finding · Incident cirrhosisResult — go to the resultHazard ratio 2.60 95% CI 1.54–4.38Authors' conclusion
FMF was associated with incident cirrhosis, irrespective of the traditional risk factors for metabolic syndrome, suggesting the contribution of the inflammatory state to the development of cirrhosis.
Study context
- Population
- Adults (≥18) in the Maccabi Healthcare Services database, 2000–2022, without chronic liver disease or cirrhosis, not treated with MTX, amiodarone or tamoxifen, with ≥12 months follow-upmatched cohort
- Exposure
- FMF vs age and gender-matched controls
- Outcome
- Incident cirrhosis (new ICD-9 diagnosis 571.5, new major cirrhotic complications or liver transplantation)
Methodological detailspopulation-based, 1:1 age and gender-matched, Cox proportional hazards models, Kaplan-Meier curves
- Population-based
- 1:1 age and gender-matched
- Cox proportional hazards models
- Kaplan-Meier curves
Main finding
Incident cirrhosis
Hazard ratio
2.60
95% CI 1.54–4.38
P < 0.01
By group
FMFvs Control
HR 2.60 (95% CI 1.54–4.38); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Cirrhosis-free survival rate · 7 years
P < 0.01
Original publication
The association between familial Mediterranean fever and incident cirrhosis: A population-based matched cohort study. Joint Bone Spine. Published 30 April 2025. doi:10.
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