Autoinflammatory & rare systemic diseases
Prevalence, incidence and geographic distribution of familial Mediterranean fever in Turkey: a national cohort study
Authors' conclusion
FMF is beyond the definition of a rare disease and a significant health issue in Turkey, with a non-uniform distribution influenced by both genetic and historical factors.
Study context
- Population
- Nationwide population of Turkey in e-Pulse; Familial Mediterranean Fever (FMF) identified by ≥2 ICD-10 codes ≥30 days apart; aged ≥50 and gout-related codes excluded160,897 FMF patients
- Participants
- 82,003,882 participants
- Outcome
- Prevalence and incidence of FMF
- Follow-up
- 2018
Methodological detailsnationwide, electronic medical records database (e-Pulse)
- Nationwide
- Electronic medical records database (e-Pulse)
Main finding
As reported in the abstract
Prevalence per 10,000 individuals
139
Incidence per 10,000
2.78
Observational data: associations, not effects.
Further findings
Age distribution
- Highest number of records among individuals aged 15-19
Geographic distribution
- Highest prevalence in Ardahan, Bayburt and Sivas (North-Eastern Turkey)
Children <18 with FMF with at least one parent diagnosed with FMF
- Proportion of children <18 with FMF with ≥1 parent with FMF
- 11.7%
Original publication
Prevalence, incidence and geographic distribution of familial Mediterranean fever in Turkey: a national cohort study. Clin Exp Rheumatol. Published 6 December 2024. doi:10.
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