Autoinflammatory & rare systemic diseases
Familial Mediterranean fever in patients with inflammatory bowel diseases: a nationwide study from the epi-IIRN
Main finding · FMF prevalenceResult — go to the resultOdds ratio 2.68 95% CI 2.2–3.3Authors' conclusion
FMF is more prevalent in IBD patients than in the general population, particularly in CD. The diagnosis of FMF precedes the diagnosis of IBD in most cases, and may be associated with a more severe course in UC.
Study context
- Population
- epi-IIRN cohort, 98% of Israel's population; Familial Mediterranean fever (FMF) by ICD-9 codes and colchicine purchasematched cohort
- Participants
- 34,375 vs 93,602
- Exposure
- Inflammatory bowel diseases (IBD) patients vs matched non-IBD controls
- IBDn = 34,375
- Non-IBD controlsn = 93,602reference
- Outcome
- Adjusted prevalence of FMF
Methodological detailsnationwide, matched controls, population-based (epi-IIRN)
- Nationwide
- Matched controls
- Population-based (epi-IIRN)
Main finding
FMF prevalence
Odds ratio
2.68
95% CI 2.2–3.3
P < 0.001
Events by group
IBDvs Non-IBD controls
OR 2.68 (95% CI 2.2–3.3); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| FMF prevalence, pediatric-onsetvs adult-onset IBD (subgroup)Without statistical significance | 1.31 (0.88–1.96) | P = 0.2 | |
| FMF prevalence, CDvs UC (subgroup) | 2.1 (1.5–3.0) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- FMF diagnosis preceding IBD diagnosis
- 83% · 130/157 of 34 375
- FMF prevalence, pediatric-onset vs adult-onset IBD (subgroup): Pediatric-onset IBD 0.6%
- FMF prevalence, pediatric-onset vs adult-onset IBD (subgroup): Adult-onset IBD 0.4%
- FMF prevalence, CD vs UC (subgroup): CD 0.6%
- FMF prevalence, CD vs UC (subgroup): UC 0.3%
Disease course with vs without FMF
- FMF associated with more severe disease activity at diagnosis in UC, but not in CD
- Outcomes comparable between CD+FMF and CD alone
- Shorter time to biologic treatment in UC+FMF
Original publication
Familial Mediterranean fever in patients with inflammatory bowel diseases: a nationwide study from the epi-IIRN. Rheumatology (Oxford). Published 30 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →