Autoinflammatory & rare systemic diseases
Adherence to colchicine prophylaxis among patients with familial Mediterranean fever treated with interleukin-1 inhibitors
Authors' conclusion
In contrast to initial concerns, adherence to colchicine was similar between patients with crFMF and csFMF. However, in both groups, adherence to colchicine was poor.
Study context
- Population
- Patients with familial Mediterranean fever (FMF) in the databases of Maccabi Health Services, Israelfinal cohort
- Participants
- 4,526 patients
- Exposure
- Colchicine-resistant FMF treated with IL-1 inhibitors vs colchicine-sensitive FMF treated only with colchicine
- crFMFn = 108
- csFMFn = 432reference
- Outcome
- Medication possession ratio (MPR) for colchicine, from first to last colchicine purchase
Methodological detailsmatched 1:4, health provider database
- Matched 1:4
- Health provider database
Main finding
As reported in the abstract
Total MPR
crFMF
78.9
mean · SD 41.4
csFMF
82.5
mean · SD 80.6
P = 0.5
Observational data: associations, not effects.
Further findings
Medication possession ratio (MPR) by age or duration of colchicine use
- No statistically significant differences in MPR between groups
Insufficient adherence (MPR<80%)
- More than 50% of patients in both groups
Original publication
Adherence to colchicine prophylaxis among patients with familial Mediterranean fever treated with interleukin-1 inhibitors. Semin Arthritis Rheum. Published 4 May 2023. doi:10.
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