Autoinflammatory & rare systemic diseases
Disentangling the hepatic risks of familial Mediterranean Fever and colchicine: A propensity score-matched analysis of 19,231 patients
Authors' conclusion
FMF is independently associated with increased hepatic injury risk, while colchicine treatment does not appear to confer additional liver toxicity.
Study context
- Population
- Patients diagnosed with Familial Mediterranean Fever (FMF), gout, pseudogout, or pericarditis; tertiary care centre in Israel
- Participants
- 19,231 patients
- Exposure
- FMF vs no FMF; colchicine vs no colchicine
- Outcome
- Liver cirrhosis and fatty liver disease (ICD codes, imaging, biopsy data)
Methodological detailspropensity score matching, multivariate logistic regression, single tertiary care centre
- Propensity score matching
- Multivariate logistic regression
- Single tertiary care centre
Main finding
As reported in the abstract
Cirrhosis
Odds ratio (95% CI)
FMFvs Non-FMFboth in unmatched and matched cohorts
4.00(2.78–5.75)
Colchicinevs No colchicine
0.92(0.69–1.22)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Fatty liverFMFvs Non-FMFBoth in unmatched and matched cohorts | 2.03 (1.57–2.61) | |
| Fatty liverColchicinevs No colchicine | 1.01 (0.85–1.21) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Disentangling the hepatic risks of familial Mediterranean Fever and colchicine: A propensity score-matched analysis of 19,231 patients. Semin Arthritis Rheum. Published 28 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →